Summary: How chromosome organization is related to genome function remains poorly understood.Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression.Here, we examine chromosome conformation in embryonic stem cells lacking cohesin and find, as in other

Smart polymers as ideal drug nanocarriers have attracted much attention due to the effective drug delivery, internalization and release once triggered Thermometer Probes by intracellular stimuli, as well as reduced cytotoxicity.We here reported the anionic micelle consisting of copolymer (PEG-b-PAsp) and a PBE (Phenylboronic Ester) group grafted, w

Based on the building of a kindergarten in Weinan, Shaanxi Province, this Shooting Jackets paper explores the influence of different envelope structures and heating modes on the indoor thermal environment for the energy saving and thermal comfort of the existing buildings.Using operating temperature as the evaluation index of thermal comfort, the 1

In this paper, we present an in-depth analysis of Central Bank Digital Currencies (CBDCs), focusing on their definition, purpose, design considerations and recent developments.We also delve into the potential advantages of CBDCs for Asia, such as enhancing convenience, precisely quantifying economic metrics, managing anonymity, catalyzing innovatio

Due to the rapid development of sensor technology and the popularity of the Internet, not only has the amount of digital information transmission skyrocketed, but also its acquisition and dissemination has become easier.The study mainly investigates One-Piece Ostomy Pouch audio security issues with data compression for private data transmission on